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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Gossypol, Gefitinib
Phytochemical Name Gossypol (PubChem CID: 3503 )
Anticancer drug Name Gefitinib (PubChem CID: 123631 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 468
Ref_1
Pair Name Gossypol, Gefitinib
Disease Info [ICD-11: 2C25.Z] Lung cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BCL-xL hsa598
Up-regulation Cleavage CASP3 hsa836
Down-regulation Phosphorylation EGFR hsa1956
Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Phosphorylation MAPK1 hsa5594
In Vitro Model PC-9-GR-high Lung adenocarcinoma Homo sapiens (Human) CVCL_S706
NCI-H1975 Lung adenocarcinoma Homo sapiens (Human) CVCL_1511
Result AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations.
03. Reference
No. Title Href
1 AT-101 enhances gefitinib sensitivity in non-small cell lung cancer with EGFR T790M mutations. BMC Cancer. 2016 Jul 18;16:491. doi: 10.1186/s12885-016-2519-3. Click
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